Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
نویسندگان
چکیده
منابع مشابه
Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
During somitogenesis, pairs of epithelial somites form in a progressive manner, budding off from the anterior end of the pre-somitic mesoderm (PSM) with a strict species-specific periodicity. The periodicity of the process is regulated by a molecular oscillator, known as the "segmentation clock," acting in the PSM cells. This clock drives the oscillatory patterns of gene expression across the P...
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The microarray technology allows researchers to simultaneously measure gene expression levels of thousands of genes. Analysis of data produced by such experiments provides knowledge about the gene function. An important step in the analysis of gene expression data is the detection of genes with similar expression patterns. Real-time computational tools for organization and visualization are cru...
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K-means and its many variants are widely used in bioinformatics. However, one of the drawbacks is that the clustering results are dependent of the initial choice of centroids, hence the experimental results are less reproducible. In addition, poor handling of nonspherical clusters is another weakness of the K-means algorithm. Thus, we investigate spectral clustering on temporal gene expression ...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2017
ISSN: 1940-087X
DOI: 10.3791/55127